MECHANISM OF BAZHEN DECOCTION IN THE TREATMENT OF COLORECTAL CANCER BASED ON NETWORK PHARMACOLOGY, MOLECULAR DOCKING, AND EXPERIMENTAL VALIDATION

Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation

ObjectiveBazhen Decoction (BZD) is a common adjuvant therapy drug for colorectal cancer (CRC), although its anti-tumor mechanism is unknown.This study aims to explore the core components, key targets, and potential mechanisms of BZD treatment for CRC.MethodsThe Traditional Chinese Medicine Systems Pharmacology (TCMSP) was employed to acquire the BZ

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Anti-Tumor Efficacy of Oleuropein-Loaded ZnO/Au Mesoporous Silica Nanoparticle in 5-FU-Resistant Colorectal Cancer Cells

Sang Mi Park,1,2 Da Yeon Kim,3 Kyeong Hyeon Lee,1 Yong-Il Shin,1,4 Sang-Cheol Han,5 Sang-Mo Kwon1,2 1Department of Physiology, Laboratory of Vascular Medicine and Stem Cell Biology, School of Medicine, Pusan National University, Yangsan, Republic of Korea; 2BK21 GRAND Convergence Medical Science Education Research Center, Pusan National University,

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How should autonomous vehicles drive? Policy, methodological, and social considerations for designing a driver

Abstract Autonomous vehicles (AVs) are being developed, tested, and commercialized around the world.While skilled human drivers can rely on their experience and common sense to navigate complex driving situations that involve trade-offs between competing objectives, AVs are engineered systems, which may handle complex scenarios based on driving pri

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